Biological sciences
7 published articles
Dorsal design variation and melanin associated pigmentation in preserved specimens of Pristimantis bogotensis (Anura: Craugastoridae)
Valentina Zuluaga Cajiao
Phenotypic variation in dorsal design patterns and pigmentation represents an important component of amphibian diversity and may be influenced by genetic, developmental, and environmental factors. However, the characterization of these traits using preserved specimens requires ca…
Research articleJul 8, 2026DOI 10.61340/PBOGOTENSISAccelerating Parkinson’s Disease Discovery: An in Silico Zebrafish Predictive Model
Mwafaq Kmail, Wael Mohamed
Parkinson’s Disease (PD) remains a major neurodegenerative disorder lacking disease-modifying therapies. Traditional single model approaches often fail to capture the complex molecular, environmental, and genetic interactions that drive disease heterogeneity. This narrative revie…
Review articleMay 6, 2026DOI 10.61340/APDDISZPMFrom poisonous botanicals to precision anticancer leads: non-edible medicinal plants in oncology drug discovery
Javad Sharifi-Rad
Some of the most pharmacologically powerful plant metabolites come from species that are not edible, largely because evolution optimized them for defense rather than safety. In oncology, where many effective therapies are intrinsically hazardous, toxicity should be treated less a…
CommentaryApr 8, 2026DOI 10.61340/TOXPLTODDPlacental microRNAs as potential regulators in tumour processes
Tábata Barbosa-Rojas
Cancer cells and placental trophoblasts share striking phenotypic and molecular similarities, including rapid proliferation, angiogenesis, immune modulation, and invasive capacity. These parallels have renewed interest in the Trophoblastic Theory of Cancer, which proposes that tu…
Research articleJan 14, 2026DOI 10.61340/PLACMIRNASREELIN-COLBOS (H3447R) in Colombian oldest-old individuals, a case series
Daniel Vásquez, David Aguillón, Paula Pérez-Corredor, et al.
We previously identified REELIN-COLBOS (RELN H3447R) and APOE Christchurch (APOE R136S) as candidate gene variants associated with protection against dementia in cases at the highest risk of Alzheimer’s Disease (AD) due to the PSEN1 E280A mutation in Colombia. Here, we examined t…
Research articleDec 3, 2025DOI 10.61340/RCCOOPPericytes in Notch3 knockout and diabetic mice form engorged connections with vascular endothelial cells
Timothy E. Vanderleest, Harper B. Gordon, Michael O’Hare, et al.
Purpose: Pericytes, cells crucially important to maintain a healthy microvasculature, make direct connections with vascular endothelial cells, yet the functional significance of these contacts remains largely unexplored. This study aims to investigate the ultrastructural morpholo…
Research articleMay 8, 2025DOI 10.61340/PN3K1DMExploring medicinal plants as natural remedies through scientific investigation
Gerda Fouche
The use of medicinal plants dates back to ancient civilizations, with records from Mesopotamia around 2600 BC and the Egyptians’ “Ebers Papyrus” around 1550 BC detailing extensive plant-based remedies. The foundation of rational drug discovery began in the early 19th century, whe…
EditorialApr 17, 2025DOI 10.61340/EMPNR