Basic medicine
11 published articles
Accelerating Parkinson’s Disease Discovery: An in Silico Zebrafish Predictive Model
Mwafaq Kmail, Wael Mohamed
Parkinson’s Disease (PD) remains a major neurodegenerative disorder lacking disease-modifying therapies. Traditional single model approaches often fail to capture the complex molecular, environmental, and genetic interactions that drive disease heterogeneity. This narrative revie…
Review articleMay 6, 2026DOI 10.61340/APDDISZPMFrom poisonous botanicals to precision anticancer leads: non-edible medicinal plants in oncology drug discovery
Javad Sharifi-Rad
Some of the most pharmacologically powerful plant metabolites come from species that are not edible, largely because evolution optimized them for defense rather than safety. In oncology, where many effective therapies are intrinsically hazardous, toxicity should be treated less a…
CommentaryApr 8, 2026DOI 10.61340/TOXPLTODDPlacental microRNAs as potential regulators in tumour processes
Tábata Barbosa-Rojas
Cancer cells and placental trophoblasts share striking phenotypic and molecular similarities, including rapid proliferation, angiogenesis, immune modulation, and invasive capacity. These parallels have renewed interest in the Trophoblastic Theory of Cancer, which proposes that tu…
Research articleJan 14, 2026DOI 10.61340/PLACMIRNASREELIN-COLBOS (H3447R) in Colombian oldest-old individuals, a case series
Daniel Vásquez, David Aguillón, Paula Pérez-Corredor, et al.
We previously identified REELIN-COLBOS (RELN H3447R) and APOE Christchurch (APOE R136S) as candidate gene variants associated with protection against dementia in cases at the highest risk of Alzheimer’s Disease (AD) due to the PSEN1 E280A mutation in Colombia. Here, we examined t…
Research articleDec 3, 2025DOI 10.61340/RCCOOPPericytes in Notch3 knockout and diabetic mice form engorged connections with vascular endothelial cells
Timothy E. Vanderleest, Harper B. Gordon, Michael O’Hare, et al.
Purpose: Pericytes, cells crucially important to maintain a healthy microvasculature, make direct connections with vascular endothelial cells, yet the functional significance of these contacts remains largely unexplored. This study aims to investigate the ultrastructural morpholo…
Research articleMay 8, 2025DOI 10.61340/PN3K1DMRetinal cell death is primarily caspase-dependent in vitro and in a mouse model of chloroquine-induced acute retinal toxicity
Dhanesh Amarnani, Eric J. Kim, Brandon V. Duffy, et al.
Purpose: To investigate the mechanism of chloroquine-induced cell death in vitro in adult human retinal pigmented epithelial (ARPE-19) cells and murine 661W photoreceptor-derived cells and to evaluate a mouse model of acute chloroquine-induced retinal toxicity. Methods: Human R…
Research articleMay 1, 2025DOI 10.61340/RCDPCDExploring medicinal plants as natural remedies through scientific investigation
Gerda Fouche
The use of medicinal plants dates back to ancient civilizations, with records from Mesopotamia around 2600 BC and the Egyptians’ “Ebers Papyrus” around 1550 BC detailing extensive plant-based remedies. The foundation of rational drug discovery began in the early 19th century, whe…
EditorialApr 17, 2025DOI 10.61340/EMPNRDeterioro inusual y predominante de la memoria en paciente en etapa temprana de CADASIL: Cuatro años de seguimiento longitudinal a una demencia vascular hereditaria
Carolina Ospina, Dorothee Schoemaker, Lina Marcela Velilla, et al.
Introducción: Los déficits en las funciones ejecutivas y la velocidad de procesamiento han sido considerados tradicionalmente como la manifestación principal de las contribuciones vasculares al deterioro cognitivo y la demencia. Este estudio de caso describe la progresión longitu…
Case reportJul 15, 2024DOI 10.61340/AVMB3899Unusual Predominant Memory Decline in an Early-Stage CADASIL Patient: A Four-Year Longitudinal Follow-Up of Hereditary Vascular Dementia
Carolina Ospina, Dorothee Schoemaker, Lina Marcela Velilla, et al.
Introduction: Deficits in executive function and processing speed have traditionally been viewed as the chief cognitive manifestation of vascular contributions to cognitive impairment and dementia. This case study describes the longitudinal progression of cognitive symptoms in a…
Case reportJun 24, 2024DOI 10.61340/YBYK7793What is missing: “Prevent and cure Alzheimer's”
Francisco Lopera
To control the global epidemic of dementia, multidisciplinary guidelines should be directed at the healthy general population. The PREVENTION strategy should be accompanied by a strong PROMOTION strategy for healthy and successful aging that prevents the development of mild cogni…
Research articleJan 29, 2024DOI 10.61340/FJXW5132Lo que nos falta: “Prevenir y curar el Alzheimer”
Francisco Lopera
Para controlar la epidemia mundial de demencia, se deben dirigir pautas multidisciplinarias a la población general saludable. La estrategia de PREVENCIÓN debe ir acompañada de una fuerte estrategia de PROMOCIÓN para un envejecimiento saludable y exitoso que prevenga el desarrollo…
EditorialJan 29, 2024DOI 10.61340/RCNI4859