Clinical medicine
20 artículos publicados
Relationship between Purpose in Life and Executive Functions in populations with neurodegenerative conditions or preclinical cognitive risk: a scoping review
Luisa Sánchez Mejía, Paula Ospina-Lopera, Victoria Tirado et al.
Purpose in Life (PiL) refers to a self-organizing life aim central to a person’s identity in relation to personal, occupational, and lifestyle domains. Executive Functions (EF), which support planning, reasoning and problem solving are essential to goal-directed behavior and ever…
Artículo de revisión10 jun 2026DOI 10.61340/PURPOSELIFENDCognición espacial como marcador cognitivo temprano de la enfermedad de Alzheimer: una revisión del alcance (Scoping review)
Wendy´K Babilonia, Juan Pablo Sánchez Escudero
Introducción: La Cognición Espacial (CE) depende de una red funcional que involucra diversas regiones cerebrales, entre ellas el hipocampo y la corteza entorrinal, regiones que se ven afectadas de manera temprana en la enfermedad de Alzheimer (EA). Aunque diversos estudios han ex…
Artículo de investigación21 may 2026DOI 10.61340/COGNESPAADCrainio non-invasive intracranial pressure monitor for traumatic brain injury: feasibility study
Maria Roldan, Chadi Hajj, Christopher Uff et al.
Traumatic brain injury (TBI) affects approximately 70 million individuals annually worldwide, often leading to significant morbidity and mortality. Intracranial pressure (ICP) monitoring plays a vital role in managing severe TBI and other conditions associated with intracranial h…
Artículo de métodos10 dic 2025DOI 10.61340/CRAINIOFSREELIN-COLBOS (H3447R) in Colombian oldest-old individuals, a case series
Daniel Vásquez, David Aguillón, Paula Pérez-Corredor et al.
We previously identified REELIN-COLBOS (RELN H3447R) and APOE Christchurch (APOE R136S) as candidate gene variants associated with protection against dementia in cases at the highest risk of Alzheimer’s Disease (AD) due to the PSEN1 E280A mutation in Colombia. Here, we examined t…
Artículo de investigación3 dic 2025DOI 10.61340/RCCOOPPoblación de los más longevos en Colombia: un estudio piloto
Daniel Vasquez, Liliana Hincapie, Yesica Zuluaga et al.
Antecedentes: La población de adultos mayores en el mundo y en Colombia está creciendo. La población mayor de 80 años presenta necesidades y características distintas a las de los adultos mayores más jóvenes. Sin embargo, la información disponible sobre estos en Colombia es limit…
Artículo de investigación3 sept 2025DOI 10.61340/OOPCPS01From big data to personalized medicine: bioinformatics perspectives and challenges
Ilya Ioshikhes
The rapid accumulation of various types of -omics data is opening new vistas for the development of novel therapeutic approaches grounded in big data. Particularly, personalized medicine stands out as one of the most promising goals. However, it faces significant logical and math…
Editorial22 jul 2025DOI 10.61340/FBDTPM¿Qué hay detrás del signo del orador?
Sanat Phatak, Pranav Mahadevkar, Jennifer L. Ingram et al.
Contrastamos dos pacientes, uno con diabetes tipo 2 y otro con esclerosis sistémica (ES), que presentaban una restricción severa de las articulaciones de las manos. A pesar de hallazgos clínicos similares, la resonancia magnética reveló tenosinovitis inflamatoria en el caso de la…
Informe de caso16 jul 2025DOI 10.61340/WIAPS02What is in a prayer sign?
Sanat Phatak, Pranav Mahadevkar, Jennifer L. Ingram et al.
We juxtapose two patients—one with type 2 diabetes and one with systemic sclerosis (SSc)—who both exhibited severe hand joint restriction. Despite similar clinical findings, MRI revealed inflammatory tenosynovitis in SSc versus non-inflammatory fibrotic changes in diabetes. This…
Artículo de investigación30 jun 2025DOI 10.61340/WIAPS01The use of aqueous humor cfDNA for low-pass whole genome sequencing as a clinical test to identify intraocular retinoblastoma recurrence
Douglas Chigane, Drishti Pandya, Brianne Brown et al.
Objective: Patients with retinoblastoma (RB) require serial examinations under anesthesia (EUA) to assess for response to treatment and disease recurrence. Monitoring for disease recurrence is complicated in patients with loss of fundoscopic view, such as with vitreous hemorrhage…
Informe de caso3 jun 2025DOI 10.61340/UAHCTIRBROldest-old population in Colombia: A pilot study
Daniel Vasquez, Liliana Hincapie, Yesica Zuluaga et al.
Background: The population of elderly people in the world and in Colombia is growing. Thus, the population over 80 years of age has different needs and characteristics than the population of older people under 80 years of age. However, the information available for Colombia is li…
Artículo de investigación21 may 2025DOI 10.61340/OOPCPSRetinal cell death is primarily caspase-dependent in vitro and in a mouse model of chloroquine-induced acute retinal toxicity
Dhanesh Amarnani, Eric J. Kim, Brandon V. Duffy et al.
Purpose: To investigate the mechanism of chloroquine-induced cell death in vitro in adult human retinal pigmented epithelial (ARPE-19) cells and murine 661W photoreceptor-derived cells and to evaluate a mouse model of acute chloroquine-induced retinal toxicity. Methods: Human R…
Artículo de investigación1 may 2025DOI 10.61340/RCDPCDA Case of Keratomalacia in Severe Vitamin A Deficiency
Jonathan W. Deck, Athena Cohen, Joseph Raevis et al.
Vitamin A is a lipid-soluble vitamin essential for vision, playing a critical role in the function and health of the retina and cornea. While vitamin A deficiency is a common global health issue, it is relatively rare in the United States, typically occurring in the context of ma…
Informe de caso26 feb 2025DOI 10.61340/CKSVAD1701El papel del equipo de enfermería del Grupo de Neurociencias de Antioquia (GNA) en la ejecución del ensayo clínico de prevención para la enfermedad de Alzheimer familiar precoz en Colombia
Lucía Madrigal Zapata, Claudia Cristina Madrigal Mesa, Érika Gallego Álvarez et al.
El presente artículo tiene el objetivo de describir la experiencia del equipo de enfermería del Grupo de Neurociencias de Antioquia (GNA) en la atención a participantes del ensayo clínico Alzheimer’s Prevention Initiative (API) Colombia y resaltar la dimensión profesional del áre…
Artículo de investigación20 feb 2025DOI 10.61340/PEEGNAThe role of the nursing team of the Neurosciences Group of Antioquia (GNA) in the execution of the prevention clinical trial for early-onset familial Alzheimer’s disease in Colombia
Lucía Madrigal Zapata, Claudia Cristina Madrigal Mesa, Érika Gallego Álvarez et al.
This paper aims to describe the experience of the nursing team at the Neurosciences Group of Antioquia (GNA) in providing care to participants in the Alzheimer’s Prevention Initiative (API) clinical trial in Colombia, highlighting the professional role of healthcare providers fro…
Artículo de investigación17 feb 2025DOI 10.61340/RNTNGAFrom Ancient Rituals to Modern Rhinoplasty: A Historical Evolution of Nasal Reconstruction
Jonathan W. Deck, Samantha Morin, Bryan S. Torres et al.
Background and aims: As surgical practices continue to evolve, the origins of these techniques and their respective indications are often lost over time, while in other cases they remain fundamental to modern utility. Rhinoplasty is a prime example of an operative intervention th…
Artículo de revisión3 dic 2024DOI 10.61340/FARMR6083A Novel Approach to the Levothyroxine Absorption Test Using Only Two Free T4 Measurements
Carlos A. Builes-Barrera, María Carolina Fragozo-Ramos, Carlos E. Builes-Montaño
Background and aims: Levothyroxine (LT4) pseudomalabsorption is a factitious disorder. The LT4 absorption test is a non-invasive method for distinguishing true LT4 malabsorption from LT4 pseudomalabsorption in people with hypothyroidism. This study aimed to evaluate a simplified…
Artículo de investigación3 oct 2024DOI 10.61340/HFQG5777Deterioro inusual y predominante de la memoria en paciente en etapa temprana de CADASIL: Cuatro años de seguimiento longitudinal a una demencia vascular hereditaria
Carolina Ospina, Dorothee Schoemaker, Lina Marcela Velilla et al.
Introducción: Los déficits en las funciones ejecutivas y la velocidad de procesamiento han sido considerados tradicionalmente como la manifestación principal de las contribuciones vasculares al deterioro cognitivo y la demencia. Este estudio de caso describe la progresión longitu…
Informe de caso15 jul 2024DOI 10.61340/AVMB3899Unusual Predominant Memory Decline in an Early-Stage CADASIL Patient: A Four-Year Longitudinal Follow-Up of Hereditary Vascular Dementia
Carolina Ospina, Dorothee Schoemaker, Lina Marcela Velilla et al.
Introduction: Deficits in executive function and processing speed have traditionally been viewed as the chief cognitive manifestation of vascular contributions to cognitive impairment and dementia. This case study describes the longitudinal progression of cognitive symptoms in a…
Informe de caso24 jun 2024DOI 10.61340/YBYK7793What is missing: “Prevent and cure Alzheimer's”
Francisco Lopera
To control the global epidemic of dementia, multidisciplinary guidelines should be directed at the healthy general population. The PREVENTION strategy should be accompanied by a strong PROMOTION strategy for healthy and successful aging that prevents the development of mild cogni…
Artículo de investigación29 ene 2024DOI 10.61340/FJXW5132Lo que nos falta: “Prevenir y curar el Alzheimer”
Francisco Lopera
Para controlar la epidemia mundial de demencia, se deben dirigir pautas multidisciplinarias a la población general saludable. La estrategia de PREVENCIÓN debe ir acompañada de una fuerte estrategia de PROMOCIÓN para un envejecimiento saludable y exitoso que prevenga el desarrollo…
Editorial29 ene 2024DOI 10.61340/RCNI4859